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It inhibits apoptosis of skeletal muscle mitochondria in IBM rats, upregulates the levels of PGC-1, NRF-1, NRF-2, Tfam, TOM40, TOM20 and TIM-related protein 23 (TIM-23), promotes mitochondrial biogenesis in IBM rat skeletal muscle, upregulates the expression of PINK1 and Parkin proteins, downregulates the LC3-II/LC3-I ratio and the levels of p62 proteins, increases the levels of IBM rat skeletal muscle mitophagy level, decreases IBM rat skeletal muscle Drp-1 and Fis-1 protein expression, upregulates the levels of SIRT3 and its downstream protein FOXO3a, and simultaneously increases SOD-2 and CAT expression, along with improving the mitochondrial dynamics and antioxidant capacity of IBM rat skeletal muscle (Koo et al., 2019)

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Consistency Matters Regular Schedule: Taking Sermorelin at the same time each day ensures steady hormone levels