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Discontinuation might be a factor limiting neuroprotective benefits of GLP1 receptor agonists

Pill swallowing by adults with dysphagia

In contrast, lean male and female PAR2-R38E mice showed a significant reduction not only in postprandial GIP, but also in GLP-1 levels in the plasma (Figure 1, G and H), suggesting that additional proteases directly or indirectly participated in GLP-1 regulation specifically during food intake

As usual, the truth lies somewhere in the middle