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The trial randomised 2,339 adults with obesity (or overweight with a weight-related comorbidity) and without type 2 diabetes to retatrutide 4mg, 9mg, or 12mg weekly (titrated upward from 2mg in four-weekly steps) or placebo

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a , Comparison of proportions of neurons activated by nutritive (Ensure, blue), aversive (cinacalcet, pink), or both (green) stimuli in AP GLP1R and NTS GLP1R neurons across one z-level from each of two example mice chosen at random, after imaging analysis following different motion correction strategies

Omega-3 fatty acids: 1,000-2,000 mg EPA/DHA daily for cardiovascular and anti-inflammatory support

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