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An error in dilution math means every subsequent measurement is fundamentally flawed

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Glutathione depletion impacts the gamma glutamyl cycle in the liver by increasing the activity of -glutamyl cysteine synthetase and accumulation of -glutamyl cysteine, which is converted by -glutamyl cyclotransferase to pyroglutamic acid/5-oxyproline [3, 4] (Fig

[Note: Four weeks was selected as the optimal time point representing advanced disease because our previous experience with this model has demonstrated that at 4 weeks, primary tumours are well established, and the cancer has metastasised