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By month 3, cumulative weight loss often reaches 1015% of starting body weight for consistent users

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Evaluation of fat mass and lean mass using Echo-MRI and X-ray CT system Consistent with the significant increase in body weight, vehicle-treated MC4R KO mice showed a significant increase in fat and lean masses

Barbeau PA, Houad JM, Huber JS, Paglialunga S, Snook LA, Herbst EAF, Dennis K, Simpson JA, Holloway GP (2020) Ablating the Rab-GTPase activating protein TBC1D1 predisposes rats to high-fat diet-induced cardiomyopathy