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An appropriate family history may increase the index of suspicion
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10,15,18,23 One trial specifically investigated BD, 11 while another 19 included a small subgroup of nine patients with bipolar depression alongside its primary MDD population
Symbiotic bacteria have the ability to stimulate dendritic cells (DCs) via their antigen presentation, toll-like receptor (TLR)-4 is activated, causing inflammasome overexpression of the downstream NLRP3 nucleotide-binding oligomerization domain-like receptor family (Wood et al., 2019)
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