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Some peptides that upregulate the production of growth hormone (GH) by the pituitary, such as sermorelin (GRF 1-29), tesamorelin, and CJC-1295, can also lead to increased levels of GH's main anabolic mediator, insulin-like growth factor 1 (IGF-1)
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However, when the landmark trials of semaglutide (STEP 1) and tirzepatide (SURMOUNT-1) measured body composition, they found that in some analyses, around 40% of weight loss came from LBM
Ohl K, Tenbrock K, Kipp M
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