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As mentioned, GLP-1RAs can reduce the content of systemic inflammation markers

Numerous studies have investigated the expression patterns of endogenous GLP-1 and GLP-1R in the central nervous system (CNS) and the peripheral nervous system, with a consensus that these are expressed on neurons and found in most areas of the brain and gutbrain axis 2

However, other experts, like researchers at the University of Southern California, think GLP-1s would have much greater cost savings, estimating theyd save up to $245 billion in the first 10 years if private insurers also covered the medications

Zepbound users lose an average of 48 lbs (at highest dose) in the first year vs Trulicity's average of 7-11 lbs

Who Might Benefit More : Retatrutide could be better for those needing substantial weight loss, while tirzepatide is a solid option for managing type 2 diabetes by itself or along with weight loss