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However, the issue of rebound upon drug withdrawal remains an unmet need in the GLP-1R agonist space, says GlobalData

This, in turn, raises circulating insulin-like growth factor-1 (IGF-1) levels

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doi: 10.1210/er.2017-00073 19 MassiminoMSciaccaLParrinelloN

For the mechanism, dosing, and timing in depth, see our guides on when to take creatine, creatine HCl vs monohydrate, and whether creatine causes weight gain