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Native GLP-1 has a short half-life of 12 min owing to rapid degradation by dipeptidyl peptidase-4 (DPP-4) [15]

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Some reactions were related to gastrointestinal adverse reactions and volume loss associated with semaglutide

The GLP-1 receptor: a key target in glucose and appetite regulation The glucagon-like peptide-1 receptor (GLP-1R) is a GPCR found primarily in pancreatic -cells, brain, heart, kidney, and the gastrointestinal tract

Phase 3 trials will provide longer-duration data, larger participant numbers, and more diverse populations