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But if you're thinking like much of the media suggests that GLP1s are gonna be a panacea for mental health, Santa has brought some bad news this Christmas recently, the GLP1s disappointed in several neuropsychiatric outcomes, in a randomized trial of major depression, failing to reduce depression or improve cognition in the first randomized trial to test that use, and failing to prevent cognitive decline in two large, industry-sponsored trials of dementia

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Network dose-response meta-analysis estimates by dose, and nonparametric monotonic increasing model plots were employed to assess the trends in adverse effects with increasing doses

Maintaining adequate caloric intake is essential to ensure balanced nutrition while on a GLP-1 medication.