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Combined oral contraceptives and/or antiandrogens versus insulin sensitizers for polycystic ovary syndrome: a systematic review and metaanalysis

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Highlights Sodium-glucose cotransporter-2 inhibitors (SGLT2-i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) provide modest but clinically meaningful blood pressure (BP) lowering effects in people with hypertension and cardiometabolic comorbidities

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The FDA Adverse Event Reporting System (FAERS)a key post-marketing surveillance toolaggregates global spontaneous AE reports, facilitating detection of rare/long-term risks