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A critical reassessment of historical failures reveals that many appetite-related peptide programs were abandoned not because their biology was flawed, but because early development conflated dose-dependent adverse effects or behavioral complexity with intrinsic target unsuitability (Lau et al., 2015

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References consulted in writing this post: Alexandra M Bodnaruc 1, Denis Prudhomme 2, Rosanne Blanchet 3, Isabelle Giroux 4 Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review