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Exogenous GLP-1 can protect the intestinal tract from oxidative damage, regulate intestinal homeostasis through local effects, and restore intestinal integrity ( Effect of GLP-1RAs on Inflammatory Response Induced by Sepsis In an observational study of patients with sepsis, it was found that endogenous GLP-1 was activated during sepsis, and GLP-1 levels were significantly elevated in patients with sepsis who died early (24 days post-admission) (Perl et al., 2018)

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