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DHEA-S & the Central Nervous System For many years, DHEA has been regarded as inactive and merely a forerunner of androgens and estrogens in the periphery this observation was based on the inability to detect classical nuclear DHEA receptors observed those for other steroid hormones (estrogens ER, progestogens PR, androgens AR, glucocorticoids GR, mineralocorticoids MR)

While these findings implicate T cellintrinsic GLP-1R signaling, definitive attribution awaits studies employing T cellspecific GLP-1R knockout models

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Endocrinology (2010) 151:152031

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