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Consistent with negative feedback by p21 on p53 levels (Broude et al, 2007), induction of p21 FL and p21 N , but not p21 C , decreased basal p53 levels and attenuated p53 stabilization upon nutlin-3 treatment, further validating the function of these proteins (Fig 2E)

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[46] Most consumers at typical energy drink consumption levels remain well below the established acceptable daily intake

Here, we review clinical trials that provide the rationale for targeting ferroptosis to delay the pathogenesis of Alzheimers disease (AD), potentially of relevance to other neurodegenerative diseases