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Type 1 diabetes patients do not have amylin treatment and, therefore, have unphysiological postprandial glucagon secretion, fast gastric emptying, and impaired satiety signaling, all of which are factors that can contribute to glycemic variability, postprandial hyperglycemia, and weight gain in intensive insulin therapy

Belisle SE, Leka LS, Dallal GE, Jacques PF, Delgado-Lista J, Ordovas JM, et al

Dementia Trialists Collaboration JAMA 1998

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For peptides, it creates repeated micro-temperature excursions that accelerate degradation over time