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Pain in the Back, Side, or Groin : Kidney infections typically cause pain in the lower back or sides, just below the ribs

This shows that staying hydrated is very important

Individual variation is significant, likely depending on baseline GLP-1 receptor density, drinking patterns, genetic factors, and dose

Muscle tissue is metabolically active and supports long-term weight management, so preserving it during treatment is a top priority for sustainable results

## Efficacy: Weight Loss Results Comparison ### Phase 2 and Phase 3 Data for Orforglipron The orforglipron Phase 2 trial, published in *Nature Medicine*, randomized 272 adults with obesity to orforglipron (12 mg, 24 mg, 36 mg, or 48 mg daily) or placebo over 36 weeks