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An imbalance of glutathione is present in many pathologies including cancer, neurodegenerative disorders, cystic fibrosis (CF), HIV and aging

Found endogenously in human plasma (~200 ng/mL at age 20), saliva, and urine, GHK-Cu forms a high-affinity complex with copper(II) ions through its histidine imidazole nitrogen and peptide backbone coordination

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10.1016/j.ejphar.2015.05.056 67 GuoJ.WangZ.WuJ.LiuM.LiM.SunY.et al (2019)

Its three-dimensional structure also comprises a predominant Rossmann-fold domain that is largely conserved, with a secondary domain including a zinc-binding module as well as a helical module