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TMEM206 plays a role in mediating acid-induced cell death as well as cell proliferation and migration, and its regulation is dependent on p53 through a p21-dependent mechanism (346)

Instead, its effects on wakefulness appear to be a downstream consequence of its interaction with major neurotransmitter systems

Often a loading dose is given in patients with severe metabolic crisis, followed by an equivalent dose over the following 24 hours

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