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Key takeaway GLP-1 medications are not simply a healthcare innovation they are emerging as a structural shift in demand for the global food system

Increasing evidence highlights the critical roles of chronic inflammation and immune dysfunction in the progression of IC/BPS (6)

The landmark work here showed that short-chain fatty acids stimulate GLP-1 release through FFAR2, in cell systems and in mice ( Tolhurst et al., 2012 )