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This creates an extraordinarily high binding affinity with pK = 16.44, approximately 10 million times higher than other tripeptides and comparable to albumins copper binding (pK = 16.2)

It can reduce IL-1 and IL-18 expression through the NF-B/NLRP3 pathway, lower blood glucose levels, and improve insulin sensitivity and insulin resistance ( Daotan Decoction has been shown to improve inflammatory responses, insulin resistance, and regulate lipid metabolism, but the mechanisms underlying these effects and their relationship with the gut microbiota remain unclear

Bailey A, Metaxas A, Al-Hasani R, Keyworth HL, Forster DM, Kitchen I

Geldanamycin, a new antibiotic