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We received no comments on our proposed adjustments to paragraphs (b)(1), (e) and (f)

-amyloid plaques are extracellular deposits of a protein fragment called -amyloid, while tau protein tangles are intracellular aggregations of hyperphosphorylated tau protein

Glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) are two major gut hormones that stimulate insulin secretion

Urine was collected weekly to confirm clearance of bacteriuria

Hexokinase (HK) phosphorylates glucose to glucose-6-phosphate (G6P), which is further metabolized to 2-phosphoglycerate by enolase and then to phosphoenolpyruvate (PEP) [14]