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Rybelsus uses a SNAC (sodium N-[8-(2-hydroxybenzoyl) amino] caprylate) absorption enhancer that creates a localized pH change in the stomach, allowing semaglutide to cross the gastric mucosa

Enrolling 17,604 adults aged 45 or older with established cardiovascular disease and a BMI of 27 or higher (without diabetes), SELECT showed that semaglutide 2.4 mg reduced the composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke by 20% over a mean follow-up of nearly 40 months