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Reduced glutathione levels have been linked to conditions and problems including: Alzheimers Cancer Chronic liver disease Cognitive impairment Diabetes High blood pressure Infertility Mental health disorders Multiple sclerosis Parkinsons disease Neurodegenerative disorders Glutathione Basics Glutathione is a powerful antioxidant found in every cell in your body

This transport dissipates any concentration gradient between cytoplasm and mitochondrial whose concentrations are both * 5 mM

10.1007/s11010-021-04112-6 82 LuoL

If a reactive intermediate is produced faster than glutathione and other Phase II systems can neutralize it, oxidative stress and liver injury may increase

Mol Pharmacol 60:5362 [DOI] [PubMed] [Google Scholar] Liu XY, Liu ZC, Sun YG, Ross M, Kim S, Tsai FF, Li QF, Jeffry J, Kim JY, Loh HH, et al