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In addition to vasoprotection, oral administration of quercetin-3- O -gentiobiose (2575 mg/kg) once daily for two weeks considerably improved the endurance capability of rats against fatigue, decreased serum blood urea nitrogen (BUN) and lactic acid levels, enhanced the activities of antioxidant enzymes (SOD, glutathione peroxidase) and attenuated inflammatory cytokine levels (MCP-1, IL-6 and TNF-)

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Patients with demanding weekday responsibilities may prefer weekend injections when they have greater flexibility to rest if side effects occur

Additionally, metformin has demonstrated anti-inflammatory effects through the inhibition of IL-18 expression, which is linked to alterations in the intestinal microbiome (Lee et al., 2019)