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10.1038/ncomms15623 Nat

Low Wang played a pivotal role in shaping these new recommendations for people with Type 2 diabetes and increased body weight

In Wistar rats, the age-dependent decline in -cell function and the subsequent impairment in glucose tolerance were reversed by GLP-1 administration [37]

usually resolves within 12 weeks per dose Diarrhoea particularly during the first 46 weeks Constipation often develops in weeks 412 as gastric emptying slows Abdominal discomfort and bloating Reduced appetite this is the therapeutic effect, but can feel intense at first Fatigue often related to reduced caloric intake rather than the drug itself Discontinuation rates in ATTAIN-1 were higher with orforglipron than placebo typically due to persistent GI symptoms during dose escalation

Promising, but still unproven at the level of evidence you'd want before calling it a first-line treatment