Given that TNF- and IL6 have been demonstrated to enhance ceramide production [36, 37], we propose that senescent granulosa cells may contribute to ceramide accumulation through autocrine or paracrine secretion of TNF- and IL6
The emerging research is clear enough to justify a more thoughtful approach
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True metabolic healing that lasts requires deeper work that targets: Insulin resistance at the cellular level Chronic inflammation that affects ovulation and egg quality Nutrient deficiencies like zinc, magnesium, vitamin D, and choline Hormone signaling issues , including leptin resistance, estrogen dominance, or HPA axis dysregulation Without resolving these, even if your weight drops, your body may still perceive pregnancy as unsafe
The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA(A) receptors