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incr odds of ACR20 (RR=1.15), ACR50 (RR=1.14) & reduced GI adverse events (RR=0.58), diarrhea (RR=0.42): BUT no difference in ACR70, DAS28-ESR, bioavailability AUC, or other AE To view or add a comment, sign in Here is How Combining Digoxin with Furosemide can significantly increase the risk of Digoxin toxicity

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However, long-term use may increase the risk of squamous cell skin cancer and melanoma (Archier 2012)

OConnor 2003)

Based on gastrointestinal safety findings, most digestive symptoms are mild to moderate