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It is crucial to understand that semaglutide's effects on insulin resistance are largely mediated through weight reduction and improved glycemic control rather than direct insulin-sensitizing action like metformin or thiazolidinediones

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As the dose increases, the appetite control and weight loss effects may become stronger

These findings contrast those of a similar study of bariatric surgery stigma, which found that higher-weight targets without a stated weight loss history were stigmatized more (i.e., rated as less desirable mates) than normal-weight targets who had undergone bariatric surgery [26]