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Sometimes, maintaining a lower dose for a longer period before escalating, or even reducing the dose temporarily, can improve tolerability whilst still providing therapeutic benefit

In lysosomes, the Fenton reaction involving iron ions produces OH, but the presence of GPX4 helps prevent membrane lipid peroxidation [145]

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O-GlcNAc-mediated FTH1 degradation is involved in smoking-induced emphysema through iron ion disorder in alveolar epithelial cells

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