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Common types of MC4R dysfunction Many variants (e.g., Ser127Leu) exhibit multiple concurrent functional defects, and the majority follow a dominant inheritance pattern consistent with haploinsufficiency [29]

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[DOI] [PubMed] [Google Scholar] 19.Gimbrone MA, Jr, Aster RH, Cotran RS, Corkery J, Jandl JH, Folkman J, et al