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We found a significant reduction in the GSH/GSSG ratio in the GR-deficient strain compared to the WT strain ( P = 0.0011), indicating severe oxidative stress (Figure 6A)

doi: 10.3945/ajcn.114.086918 Summary Keywords nutritional interventions, osteoarthritis, metabolism, inflammation, oxidative stress, gut-joint axis Citation Wang Y, Cao Z, Gao Y, Shao P, Gao S, Dong M, Tian Z, Feng Y, Xu J and Xiang C (2025) Nutritional interventions for osteoarthritis: targeting the metabolism-inflammation-oxidative stress axisclinical evidence and translational practice

It acts as an antioxidant and helps to prevent cellular damage and neutralize free radicals