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While these drugs have become very popular, they are not without risks

In 2026, GLP-1 prescribing is no longer confined to a single specialty

CagriSema (cagrilintide plus semaglutide) is the most advanced combination in development, pairing GLP-1 agonism with amylin receptor agonism

Research suggests that berberine may: Improve insulin sensitivity Support healthy glucose metabolism Influence gut microbiota composition Enhance pathways involved in GLP-1 secretion Other ingredients that may support GLP-1 activity include: Prebiotic fibers like inulin Polyphenols from green tea Omega-3 fatty acids These nutrients work by supporting metabolic processes linked to increase GLP-1 naturally, rather than directly mimicking the hormone

Weve also seen this from real-world data