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At 2 mg/mL, this equals 0.4 mg

Out of various reasons of appearance of drug resistance, genome plasticity is another key factor in the survival of Leishmania parasites and their development of drug resistance in which genetic variations such as mutations, gene amplifications, and chromosomal rearrangements play crucial roles in the appearance of resistance (Kamran et al., 2023)

79 While the direct renoprotective mechanisms of GLP-1RAs are still under investigation, their ability to enhance natriuresis and suppress pathogenic angiotensin II production presents a valuable therapeutic strategy in HFpEF complicated by CKD

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It has been well established that pro-inflammatory cytokines produced by the adipose tissue in obesity affect normal nutrition-related signalling, establishing the progression to MetS and ultimately to T2D [125]