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Mean values of normal controls (meanSD, n = 7)

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Insulin induces SREBP-1c maturation via a proteolytic mechanism started in the endoplasmic reticulum (ER), wherein hepatic IR is highly associated with hepatic steatosis

In addition to sharing similarities in drug formulation, the drugs have both been associated with an increased risk of gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation