CHRs should strive to ensure smooth turnaround which can further be helped by ePRO vendors
1 Irregular heartbeats Across Phase 2 and Phase 3 trials, irregular heartbeats were reported in 2 to 11% of people on retatrutide, compared with around 2% on placebo
Takeaway: Dont fixate on which specific GLP-1 youre taking
2015;115(11):1861-1870.) The best fiber sources for semaglutide and other GLP-1 users: Non-starchy vegetables broccoli, Brussels sprouts, carrots, leafy greens like spinach, kale, and Swiss chard Whole grains oats, quinoa, and brown rice provide sustained energy and steady blood sugar Legumes their fiber-protein combination is nearly unmatched for GLP-1 users Low-sugar fruits berries (blueberries, strawberries, raspberries) offer antioxidants and fiber with less sugar impact than most other fruits If you're new to GLP-1 medications, increase fiber gradually
regular eye exams for people with diabetes Suicidal Thoughts or Behavior : Warning : FDA is investigating reports of suicidal thoughts and behaviors in people taking GLP-1 medications Causality not established, but monitoring warranted Symptoms : New or worsening depression Thoughts of suicide or self-harm Unusual mood changes Increased anxiety or agitation Withdrawal from activities or relationships Action Required : Contact healthcare provider immediately Call 988 (Suicide and Crisis Lifeline) if experiencing suicidal thoughts Call 911 if immediate danger to self or others Inform family/friends so they can provide support and monitoring Risk Factors : History of depression or mental health conditions Previous suicidal thoughts or attempts Pulmonary Aspiration During Surgery : Risk : GLP-1 medications slow gastric emptying Stomach may contain food even after fasting During general anesthesia, stomach contents can enter lungs (aspiration) Can cause serious lung infection (aspiration pneumonia) Prevention : Inform surgeon and anesthesiologist about GLP-1 medication BEFORE any surgical procedure (even minor) Follow specific instructions about when to hold medication before surgery May need to hold medication 1 week or longer before elective surgery For emergency surgery, anesthesiologist will take special precautions Important : Don't skip informing surgical team - this is critical safety information Drug Interactions and Special Population Considerations Oral Contraceptive Effectiveness (Critical for Women of Childbearing Potential): According to FDA prescribing information: Tirzepatide (Zepbound) Specific Warning : May reduce effectiveness of oral contraceptives due to delayed gastric emptying Could result in unintended pregnancy Recommendations for Women Taking Oral Birth Control : Discuss contraception with healthcare provider BEFORE starting GLP-1 medication Consider switching to non-oral contraception methods: Intrauterine device (IUD - copper or hormonal) Contraceptive implant (Nexplanon) Contraceptive injection (Depo-Provera) Contraceptive patch Vaginal ring Permanent sterilization (if family complete) If continuing oral contraceptives, use additional barrier method (condoms) for: 4 weeks after starting GLP-1 medication 4 weeks after each dose increase Pregnancy Prevention Critical: Unintended pregnancy while taking GLP-1 medications should be avoided
