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Timing: fasted 45 minutes before and after injection
Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable
doi:10.1074/jbc.M706204200 Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ
GersingAGersingASSolkaMJosephGBSchwaigerBJHeilmeierUet al