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There is mixed evidence that high-dose vitamin E supplementation (equivalent to 180 or 360 mg/day of RRR --tocopherol from synthetic vitamin E [ dl --tocopherol]) influences the risk of heart attack in high-risk individuals (patients with coronary heart disease, type 2 diabetes mellitus, or renal failure

This intrinsic function enables melatonin to directly detoxify ROS and RNS [93]

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Serious adverse events have not been widely reported, but this may reflect the relatively small number of people who have used the compound and the limited reporting mechanisms available

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