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This selective clearance reduces the accumulation of senescent cells, restores tissue homeostasis, and supports cell cycle regulation

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In terms of mechanisms, GLP-1RAs can block C/EBP homologous protein (CHOP)-mediated endoplasmic reticulum (ER) stress via attenuating the irreversible electroporation (IRE)- unfolded protein response (UPR) [85]

SARS-CoV2 mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

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