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The Guideline 2024 multi-society guidance endorses continuing GLP-1 receptor agonists for most patients when teams evaluate and mitigate risk

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Kynurenic acid has been shown to act as a non-competitive antagonist at the glycine binding site of the NMDA receptor (NMDA: N -methyl-D-aspartate) which is an ionotropic (ligand-gated ion channel) receptor for glutamate