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Concomitantly, dysregulated GSH metabolism and impaired energy metabolism synergistically exacerbate hippocampal neuronal injury, forming a self-amplifying pathological loop (Figure 9)

Indeed, there are five CpG islands in the CBS gene locus with the longest CpG island containing 232 CG dinucleotides next to the transcription start site (Supplementary Fig

Although DSIP has demonstrated some promise as an antioxidant, antiedemic, and anticonvulsant agent, the research to date has been limited to animal studies, so its uncertain whether desired health outcomes are attainable in humans