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The current sate of knowledge has moved on in 30 odd years and yet B12 maintenance dose has since worsened

The identification of exendin-4 from Gila monster (Heloderma suspectum) saliva as a stable GLP-1 mimetic enabled appetite suppression and glycemic control in metabolic disease, driving the development of long-acting GLP-1 analogues and unimolecular agents that co-activate GLP-1 and GIP receptors (Mller et al., 2025)

Phase 2 trials will begin later this year

Patients should not purchase products claiming to contain retatrutide from unregulated sources, as these carry serious safety risks including counterfeit or incorrectly dosed products

Social dynamics shift as well, sometimes in unexpected ways