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The appearance of REES is linked to the reorientation time of the polar solvent molecules (water) surrounding an excited polar fluorophore (tryptophan) with changed electronic state (and, thus, changed dipole moment) to reach a new, lower-energy equilibrium with the excited fluorophore

That is not to say until all symptoms have "gone away" but until they no longer improve

The recommended dosage is just three sprays per day, making it a low-effort addition to your daily supplement stack