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Sensitivity analysis revealed that the overall effect size did not depend on one individual study

Plasma free fatty acid (FFA) concentrations were measured using the Free Fatty Acid Quantification Kit (Sigma-Aldrich) in separate cohorts of mice, including both sexes of whole-body Gpr146/ and Gpr146/ mice on HFD, as well as adipose-specific and liver-specific knockout models following HFD feeding

The skin's inherent protective layer, specifically the outermost layer of the epidermis, stratum corneum, is a barrier that limits the entry of large hydrophilic molecules into the skin [27]

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