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Reliable detection at the earliest signs of AD related pathology could permit drug treatment many months or even years ahead of symptoms

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Protease inhibitors (DPP4i at 24 L/600 L) and Aprotinin (9 L/600 L) were added before transfer of slices into the wells

The neuropathology consists of atrophy of the cerebral hemispheres, medial temporal lobe, thalamus, mammillary body, and brainstem, with ventricular dilation and fenestrated cavum septum pellucidum

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