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Clinical Evidence on Mood Changes: What Research Shows Meta-analyses of semaglutide trials reveal mood-related adverse events across a spectrum: some patients report improved mood (possibly via weight loss and metabolic benefits), while others experience depressive symptoms, anxiety, or emotional numbness

In Study 2, composite scores changed slightly from baseline to week 26

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However, spacing doses may help reduce stomach discomfort if both medicines cause nausea

2.1 Renal Impairment Study 2.1.1 Study Population Male and female participants of non-childbearing potential were eligible for inclusion in the renal impairment study if they were aged between 18 and 80 years with a body mass index (BMI) between 20 and 39.9 kg/m 2 and a body weight 60 kg at screening