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DOI: 10.1172/JCI116842 Borkow G

The efficacy of the new pharmacotherapies will allow clinicians to treat obesity towards individualised treatment targets, similar to what is happening with other chronic diseases such as T2D or dyslipidaemia

The critical management task is distinguishing expected pharmacodynamic discomfort from signals that warrant dose pause or permanent discontinuation

It is used in its most concentrated in the heart and skeletal muscles where it plays an important role in energy production and detoxification

As part of the phosphatidylinositol kinase-related kinase (PIKK) family, mTOR is a serine/threonine kinase that is present within the mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2)