Many of these trials recruited terminal or end-stage patients, for whom any sort of treatment is unlikely to have an effect, and they often recruited cohorts with mixed cancers, which may respond differentially to IVC depending on the underlying mechanisms involved
doi: 10.1186/1476-511X-13-78 255 SimopoulosAP
Effect of ascorbate or N-acetylcysteine treatment in a patient with hereditary glutathione synthetase deficiency
Cancer Chemother Pharmacol 67(5):11671178 Kanematsu S, Uehara N, Miki H, Yoshizawa K, Kawanaka A, Yuri T, Tsubura A (2010) Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells
In another study, researchers found that combining glutathione with L-citrulline maximizes the production of nitric oxide, which dilates the blood vessels to improve blood flow and oxygen delivery to muscles and tissue [10]