In a hydrogen peroxide-induced oxidative stress model using porcine IECs, extracellular polysaccharides from LGG accelerated ROS clearance by upregulating antioxidant enzyme expression and downregulating oxidative stress-related proteins
this was associated with induction of an irregular increase in gastric and duodenal contractility (Lucey et al., 2003)
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The reaction mechanism for roGFP2(S 2 ) as a model non-glutathione disulfide substrate resembles the first part of the GSH-dependent reduction of the sulfenic acid of human peroxiredoxin 6 that is catalyzed by glutathione transferase P1-1 (which shares several structural features with glutaredoxins) 7,80,81,82
Positive trials are needed before botulin toxin can be recommended for the management of pylorospasm in gastroparesis [5, 12], and the 2013 ACG recommendations on gastroparesis strongly advises against using botox for the treatment this condition [4]
